Protein Details: Cation channel sperm-associated auxiliary subunit gamma

Protein ID

ICDB_Pro_0952

Protein Name

Cation channel sperm-associated auxiliary subunit gamma

Gene Name

CATSPERG; QtsA-18551

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Length

1159 amino acids

AlphaFoldDB

AF-Q4R6B2-F1-model_v4.pdb

Function

Auxiliary component of the CatSper complex; a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Sequence

MCGPAMFPAGPRWPRVRVLQVLWALLAVLLASRRLWAIKDFEECTWQVVLNEFKRVGENGASDRFFEQELVDTVGNLFHMLVDSPIDPREKYLGFPYYLKINYSCEEKHSEDLVRMGHLTGLKPVVLVTFQSPVNFYRWKIEQLQIQMEAAPFRSKEPCIAEEVCSMSWYTPMPIKNGSVVTRVDVSSNGLGTFIPDKRFQVNINGFLKRNQDNDIQFTVGDELFNLMPQYFVGISSRPLWHTVDQSPVLILGGIPNEKYVLMTDTSFKDFSLVELSIDSCWVGSFYCPQSGFTATIYDTVATESTLFIRQNQLVYYFTGTYTTLYERNRGSGSWVRVLASECIKKLCPVYFHSNGSEYIMALTTGKHEGFVHFGTIRDGQVSFEMLPREWSVCEQIGVTTCSIIWSDYIAGEYTLLLLVESEYENASKRFQVVSYNTANDDLELLYHIPEFIPEARGLEFLMILGTESYTNTVMTPKGISCNPYNHLIFIWGNFLLQSSNKENFIYLADFPKELSIKYMTRSFRGAVAIVTETEEIWYLLEGTYRVYRLFPSKGWKVHISLQLMQQSSLYASNETMLTLFYEGSKLYQLVYLMNNQKGQLVKRLMPVEQLLMYQQHTSHYDLDRKGGYLMLSFTNFCPFSVMRLRNLPGPQRYTRQERYRARPPHVLERSGFHNENSLAIYQGLIYYLLWLHSVYDKPYADPVHDPTWRWWENNKQDQDYYFFLASNWRSAGGVFIEMDSYEKIYNLKSAYELPERIFLDKGTEYSFAIFLSAQSRSFRTMADLGTVFELHSHVDVGVVLADPGCIEASVKQEVLINRNAVLFSITLKDKKVCYDQGISGHHLMKSSMTVNVVGSSGLCFQETHAGARMQGNLMVPVFIGCPPGKRLAFDITYTLEYSRLKNKHYFDCVQVDPEMPCFLFRDIFYPFFLIQDLVTGDSGSFQGSYVLLVVGGGPTLDTLKDYNKDEIYRFNSPLDKTHSLIWTTRTKRTTKDSAFHIMSHESPGIEWLCLENAPCYDNVPQGIFAPEFFFKVLVSNRGVDTSTYCNYQLTFLLHIHGLPLSPKRALFILMVSLSVFVGLVIFYIAFCLLWPLVVKGCTMIRWKINDIIASESYYTYASISGMSSMQSLRRSRMGSMFSSRMTEDKAEPKEAVERQLMT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

RefSeq

NP_001306307.1;